Expression changes of nerve cell adhesion molecules L1 and semaphorin 3A after peripheral nerve injury
نویسندگان
چکیده
منابع مشابه
iTRAQ-based proteomics profiling of Schwann cells before and after peripheral nerve injury
Objective(s): Schwann cells (SCs) have a wide range of applications as seed cells in the treatment of nerve injury during transplantation. However, there has been no report yet on kinds of proteomics changes that occur in Schwann cells before and after peripheral nerve injury.Materials and Methods: Activated Schwann cells (ASCs) and normal Schwann cells (NSCs) were obtained from adult Wistar ra...
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Peripheral nerve injury can lead to great morbidity in those afflicted, ranging from sensory loss, motor loss, chronic pain, or a combination of deficits. Over time, research has investigated neuronal molecular mechanisms implicated in nerve damage, classified nerve injury, and developed surgical techniques for treatment. Despite these advancements, full functional recovery remains less than id...
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The adhesion molecule L1 is one of the few adhesion molecules known to be beneficial for repair processes in the adult central nervous system of vertebrates by promoting axonal growth and neuronal survival. In the peripheral nervous system, L1 is up-regulated by myelination-competent Schwann cells and regenerating axons after nerve damage but its functional role has remained unknown. Here we te...
متن کاملEffects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration
BACKGROUND For peripheral nerve regeneration, recent attentions have been paid to the nerve conduits made by tissue-engineering technique. Three major elements of tissue-engineering are cells, molecules, and scaffolds. METHODS In this study, the attachments of nerve cells, including Schwann cells, on the nerve conduit and the effects of both growth factor and adhesion molecule on these attach...
متن کاملThe Effect of Ultrasound on Acceleration of Peripheral Nerve Injury
Background: Many people suffer from nerve injury. The time consuming nature of the treatments makes the condition worse. Therefore, finding a way to accelerate the process of nerve repair is very important.Objective: To determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration.Methods: The experimental model included crushed rat’s sciatic nerve. 40 rats w...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2016
ISSN: 1673-5374
DOI: 10.4103/1673-5374.197148